DNAmend is cloning software. That means, it may serve lab-workers in molecular biology and genetic engineering to monitor the DNA-cloning process. The authors tried to create a PC routine, that provides on-line control on some steps of a cloning protocol - including the selection of the vectors and fragments, their processing by restrictase digestion, subsequent ligation, and the analysis of the cloned DNA. The program runs on IBM-compatibles under Microsoft Windows 3.x, Windows 95/98, NT, and XP. The software is designed to accept files containing DNA sequence information in any file format based on PC-text. A set of pull-down menu commands enables the user to change the mode of viewing the DNA-sequences, print them out, and above all manipulate them . You can search DNA sequences for restriction sites, open reading frames and certain sequence patterns, translate the sequences and simulate restriction, ligation or end modification on-line. You may export maps of your DNA-sequences via clipboard into any windows metafile using windows applications to prepare them for publication.